University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: michaelglaysher@me.com. University Hospital Southampton NHS Foundation Trust, Southampton, UK. Imperial College London, London, UK; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. Imperial College London, London, UK. School of Human Development & Health, Faculty of Medicine, University of Southampton, Southampton, UK. Imperial College London, London, UK; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland. School of Human Development & Health, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.